Archív kategorií: Krátke postrehy

Cureus | Physician Suicide in the Era of the COVID-19 Pandemic

Over the last several decades, physician burnout has become more prevalent because of increasing workloads, increasing administrative burden, and time spent on electronic medical records, among several other reasons [11]. The rate of suicidal ideation among physicians is almost twice as high as the general population at 7.2% vs. 4%. In addition, studies on mortality related to suicide show that the rates of suicides in physicians are consistently higher than in the general population

Zdroj: Cureus | Physician Suicide in the Era of the COVID-19 Pandemic

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients | NEJM

After oral administration of molnupiravir, NHC circulates systemically and is phosphorylated intracellularly to NHC triphosphate. NHC triphosphate is incorporated into viral RNA by viral RNA polymerase and subsequently misdirects the viral polymerase to incorporate either guanosine or adenosine during viral replication. This leads to an accumulation of deleterious errors throughout the viral genome that ultimately render the virus noninfectious and unable to replicate.

Zdroj: Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients | NEJM

Časté posilující dávky můžou oslabit imunitní odpověď, obává se EMA – Seznam Zprávy

Evropská agentura pro léčivé přípravky (EMA) se obává, že aplikace posilující dávky vakcíny proti covidu-19 každé čtyři měsíce časem oslabí imunitní odpověď a může lidi vyčerpat, píše agentura Bloomberg. Státy by podle EMA měly zavést delší intervaly mezi jednotlivými dávkami a načasovat termíny očkování na začátek zimní sezony.

Zdroj: Časté posilující dávky můžou oslabit imunitní odpověď, obává se EMA – Seznam Zprávy