Caffeine has differing CNS, cardiovascular, and metabolic effects based on the quantity ingested. Average doses of caffeine (85-250 mg, the equivalent of 1-3 cups of coffee) may result in feelings of alertness, decreased fatigue, and increased focus or attention. High doses (250-500 mg) can result in restlessness, nervousness, insomnia, and tremors. As the dosing increases, caffeine can eventually cause hyperadrenergic symptoms resulting in seizures and cardiovascular instability.
Zdroj: Caffeine Toxicity: Practice Essentials, Background, Pathophysiology
